Pptc7 Gene Summary [Rat]
Predicted to enable protein serine/threonine phosphatase activity and protein-macromolecule adaptor activity. Predicted to be involved in negative regulation of mitophagy and positive regulation of ubiquinone biosynthetic process. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrial outer membrane. Orthologous to human PPTC7 (protein phosphatase targeting COQ7). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pptc7 |
| Official Name | PTC7 protein phosphatase homolog [Source:RGD Symbol;Acc:1310383] |
| Ensembl ID | ENSRNOG00000021440 |
| Bio databases IDs | |
| Aliases | PTC7 protein phosphatase homolog |
| Synonyms | 9130017A15Rik, DKFZp686M07120, protein phosphatase targeting COQ7, PTC7 protein phosphatase homolog, RGD1310383, TA-PP2C, T cell activation protein phosphatase 2c |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pptc7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sigma factor PP2C-like phosphatases
- Stage II sporulation protein E (SpoIIE)
- protein serine/threonine phosphatase
- protein binding activity, bridging
- phosphatase
- protein binding
- Serine/threonine phosphatases, family 2C, catalytic domain
- PP2Cc
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- systemic juvenile idiopathic arthritis
regulated by
- bleomycin
- levodopa
- mir-582
- Tgfb
- mono-(2-ethylhexyl)phthalate
regulates
- reactive oxygen species
- adenosine triphosphate
- coenzyme Q10
- ubiquinone
role in cell
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pptc7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-serine dephosphorylation
- protein dephosphorylation
- regulation of ubiquinone biosynthetic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- protein binding
- metal ion binding
- myosin phosphatase activity