PPTC7 Gene Summary [Human]
Enables protein serine/threonine phosphatase activity. Involved in peptidyl-serine dephosphorylation and regulation of ubiquinone biosynthetic process. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PPTC7 |
| Official Name | protein phosphatase targeting COQ7 [Source:HGNC Symbol;Acc:HGNC:30695] |
| Ensembl ID | ENSG00000196850 |
| Bio databases IDs | |
| Aliases | protein phosphatase targeting COQ7, T cell activation protein phosphatase 2C |
| Synonyms | 9130017A15Rik, DKFZp686M07120, protein phosphatase targeting COQ7, PTC7 protein phosphatase homolog, RGD1310383, TA-PP2C, T cell activation protein phosphatase 2c |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPTC7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sigma factor PP2C-like phosphatases
- Stage II sporulation protein E (SpoIIE)
- protein serine/threonine phosphatase
- protein binding activity, bridging
- phosphatase
- protein binding
- Serine/threonine phosphatases, family 2C, catalytic domain
- PP2Cc
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- systemic juvenile idiopathic arthritis
regulated by
- bleomycin
- levodopa
- mir-582
- Tgfb
- mono-(2-ethylhexyl)phthalate
regulates
- reactive oxygen species
- adenosine triphosphate
- coenzyme Q10
- ubiquinone
role in cell
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPTC7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-serine dephosphorylation
- protein dephosphorylation
- regulation of ubiquinone biosynthetic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- protein binding
- metal ion binding
- myosin phosphatase activity