Ldah Gene Summary [Rat]
Predicted to enable sterol ester esterase activity. Predicted to be involved in cholesterol homeostasis; intracellular triglyceride homeostasis; and lipid storage. Predicted to act upstream of with a positive effect on lipid droplet fusion. Predicted to be located in endoplasmic reticulum. Predicted to be active in lipid droplet. Orthologous to human LDAH (lipid droplet associated hydrolase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ldah |
| Official Name | lipid droplet associated hydrolase [Source:RGD Symbol;Acc:1311648] |
| Ensembl ID | ENSRNOG00000021475 |
| Bio databases IDs | |
| Aliases | lipid droplet associated hydrolase |
| Synonyms | 1110057K04Rik, C2orf43, FLJ21820, hLDAH, lipid droplet associated hydrolase, mLDAH, RGD1311648 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ldah often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sterol esterase
- alpha/beta hydrolases
- enzyme
- Lipid-droplet associated hydrolase
Pathways
Biological processes and signaling networks where the Ldah gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- cholesterol
regulated by
- levodopa
disease
- prostate cancer
- prostatic carcinoma
- epithelial cancer
- carcinoma in situ
- epithelial cancer in situ
- luminal A breast carcinoma
- luminal A breast cancer
role in cell
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- lipid droplets
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ldah gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid storage
- lipid catabolic process
- cellular triglyceride homeostasis
- cholesterol homeostasis
Cellular Component
Where in the cell the gene product is active
- lipid particle
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- sterol esterase activity