LDAH Gene Summary [Human]

Predicted to enable lipase activity. Predicted to be involved in lipid storage. Predicted to be located in endoplasmic reticulum. Predicted to be active in lipid droplet. [provided by Alliance of Genome Resources, Apr 2022]

Details

Type
Protein Coding
Official Symbol
LDAH
Official Name
lipid droplet associated hydrolase [Source:HGNC Symbol;Acc:HGNC:26145]
Ensembl ID
ENSG00000118961
Bio databases IDs NCBI: 60526 Ensembl: ENSG00000118961
Aliases lipid droplet associated hydrolase
Synonyms 1110057K04Rik, C2orf43, FLJ21820, hLDAH, lipid droplet associated hydrolase, mLDAH, RGD1311648
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LDAH often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • sterol esterase
  • alpha/beta hydrolases
  • enzyme
  • Lipid-droplet associated hydrolase

Pathways

Biological processes and signaling networks where the LDAH gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • prostate cancer
  • prostatic carcinoma
  • epithelial cancer
  • carcinoma in situ
  • epithelial cancer in situ
  • luminal A breast carcinoma
  • luminal A breast cancer
regulated by
  • levodopa
regulates
  • cholesterol
role in cell
  • differentiation

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • Endoplasmic Reticulum
  • lipid droplets

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human LDAH gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • lipid storage
  • lipid catabolic process
  • cellular triglyceride homeostasis
  • cholesterol homeostasis

Cellular Component

Where in the cell the gene product is active
  • lipid particle
  • endoplasmic reticulum

Molecular Function

What the gene product does at the molecular level
  • sterol esterase activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.