Slc15a3 Gene Summary [Rat]
Predicted to enable dipeptide transmembrane transporter activity and peptidoglycan transmembrane transporter activity. Predicted to be involved in dipeptide import across plasma membrane; peptidoglycan transport; and positive regulation of nucleotide-binding activity oligomerization domain containing 2 signaling pathway. Located in lysosomal membrane. Orthologous to human SLC15A3 (solute carrier family 15 member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc15a3 |
| Official Name | solute carrier family 15 member 3 [Source:RGD Symbol;Acc:628663] |
| Ensembl ID | ENSRNOG00000021644 |
| Bio databases IDs | |
| Aliases | solute carrier family 15 member 3 |
| Synonyms | cI-1, hPHT2, OCTP, PHT2, PTR3, SLCL15A, solute carrier family 15 member 3, solute carrier family 15, member 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc15a3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- amide transporter
- amino acid/peptide transporter (Peptide:H+ symporter), bacterial
- Major Facilitator Superfamily
- peptide:hydrogen symporter
- protein binding
- proton-dependent oligopeptide transporter
- transporter
- peptidoglycan transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dermatomyositis
- hyperzincemia and hypercalprotectinemia autoinflammatory syndrome
- conotruncal heart malformations
regulates
- N(2)-(gamma-D-glutamyl)-meso-2,2'-diaminopimelic acid
- N-acetylmuramyl-L-alanyl-D-isoglutamine
- ion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- lysosome membrane
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc15a3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transport
- innate immune response
- protein transport
- positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
- peptidoglycan transport
- peptide transport
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- endosome membrane
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- dipeptide transmembrane transporter activity
- peptide:hydrogen symporter activity
- protein binding
- peptidoglycan transporter activity