Zbtb40 Gene Summary [Rat]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in DNA damage response and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZBTB40 (zinc finger and BTB domain containing 40). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zbtb40 |
| Official Name | zinc finger and BTB domain containing 40 [Source:RGD Symbol;Acc:1309866] |
| Ensembl ID | ENSRNOG00000022039 |
| Bio databases IDs | |
| Aliases | zinc finger and BTB domain containing 40 |
| Synonyms | C230087D24, Gm571, mKIAA0478, RGD1309866, zinc finger and BTB domain containing 40, ZNF923 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Zbtb40 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- transcription regulator
- Broad-Complex, Tramtrack and Bric a brac
- C2H2-type zinc-finger domain
- BTB_POZ
- Zinc-finger double domain
- BTB/POZ domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- gamma H2AX nuclear focus
- PML nuclear bodies
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Zbtb40 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- bone mineralization
- response to DNA damage stimulus
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- metal ion binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity