Dnmt1

Enables several functions, including DNA (cytosine-5-)-methyltransferase activity; histone deacetylase binding activity; and nuclear estrogen receptor binding activity. Involved in several processes, including cellular response to lead ion; cellular response to platelet-derived growth factor stimulus; and negative regulation of gene expression via chromosomal CpG island methylation. Located in nucleus. Part of protein-containing complex. Used to study choline deficiency disease and lung carcinoma. Biomarker of several diseases, including choline deficiency disease; congestive heart failure; fetal alcohol spectrum disorder; liver disease (multiple); and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Graves' disease; autosomal dominant cerebellar ataxia, deafness and narcolepsy; hereditary sensory neuropathy; hereditary sensory neuropathy type 1E; and lung non-small cell carcinoma. Orthologous to human DNMT1 (DNA methyltransferase 1). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dnmt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Dnmt1 gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Dnmt1 gene, providing context for its role in the cell.