Lyplal1 Gene Summary [Rat]
Predicted to enable carboxylic ester hydrolase activity and palmitoyl-(protein) hydrolase activity. Predicted to be involved in negative regulation of Golgi to plasma membrane protein transport and negative regulation of cGAS/STING signaling pathway. Predicted to act upstream of or within protein depalmitoylation. Predicted to be located in cytosol and mitochondrion. Predicted to be active in cytoplasm. Orthologous to human LYPLAL1 (lysophospholipase like 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lyplal1 |
| Official Name | lysophospholipase-like 1 [Source:RGD Symbol;Acc:1311195] |
| Ensembl ID | ENSRNOG00000023130 |
| Bio databases IDs | |
| Aliases | lysophospholipase-like 1 |
| Synonyms | BC027340, Lyplal1 predicted, lysophospholipase-like 1, Q96AV0, Q96AVO |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lyplal1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Serine hydrolase (FSH1)
- alpha/beta hydrolases
- Phospholipase/Carboxylesterase
- enzyme
- protein binding
- palmitoyl-(protein) hydrolase
- ester bond hydrolase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lyplal1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein depalmitoylation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- hydrolase activity, acting on ester bonds
- lysophospholipase activity
- protein binding
- palmitoyl-(protein) hydrolase activity
- lipase activity
- carboxylic ester hydrolase activity