Cs Gene Summary [Rat]
Enables citrate (Si)-synthase activity. Involved in several processes, including acetyl-CoA metabolic process; carboxylic acid metabolic process; and tricarboxylic acid cycle. Located in mitochondrion. Used to study congestive heart failure; hyperthyroidism; hypothyroidism; limb ischemia; and myocardial infarction. Biomarker of bipolar disorder and congestive heart failure. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and hypertrophic cardiomyopathy. Orthologous to human CS (citrate synthase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cs |
| Official Name | citrate synthase [Source:RGD Symbol;Acc:620330] |
| Ensembl ID | ENSRNOG00000023520 |
| Bio databases IDs | |
| Aliases | citrate synthase |
| Synonyms | 2610511A05Rik, 9030605P22Rik, Ahl4, BB234005, Cis, CISY, citrate synthase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cs often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Citrate synthase, C-terminal domain
- acyltransferase converting acyl groups into alkyl on transfer
- citrate (Si)-synthase, eukaryotic
- citrate (Si)-synthase
- CS_ACL-C_CCL
- enzyme
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- Alzheimer disease
- organismal death
- psoriasis
- glioblastoma
- glioblastoma cancer
- hepatitis B virus-related hepatocellular carcinoma
- liver cancer
- early onset hypertension
- androgenic alopecia
regulates
- histone H3
- DNA promoter
- DNA endogenous promoter
- FOXP3
- asparagine
- acetyl-coenzyme A
- citric acid
- oxalacetic acid
- L-aspartic acid
- malate dehydrogenase
role in cell
- expression in
- apoptosis
- production in
- josamycin sensitivity
- acetylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- mitochondrial fraction
- detergent resistant lipid raft fraction
- cellular membrane
- Mitochondria
- mitochondrial matrix
- mitoplasts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cs gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- citrate metabolic process
- tricarboxylic acid cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- citrate (Si)-synthase activity
- RNA binding