Ano7 Gene Summary [Rat]
Predicted to enable intracellularly calcium-gated chloride channel activity and phospholipid scramblase activity. Predicted to be involved in calcium activated phospholipid scrambling and chloride transmembrane transport. Predicted to act upstream of or within calcium activated phospholipid scrambling and establishment of localization in cell. Predicted to be located in endoplasmic reticulum. Predicted to be active in plasma membrane. Orthologous to human ANO7 (anoctamin 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ano7 |
| Official Name | anoctamin 7 [Source:RGD Symbol;Acc:1302987] |
| Ensembl ID | ENSRNOG00000023427 |
| Bio databases IDs | |
| Aliases | anoctamin 7 |
| Synonyms | anoctamin 7, D-TMPP, Gm598, IPCA-5, LOC108352008, NGEP, Ngep-L, PCANAP5, PCANAP5L, TMEM16G |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ano7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Calcium-activated chloride channel
- phospholipid scramblase
- dimerization domain of Ca+-activated chloride-channel, anoctamin
- chloride channel
- intracellular calcium activated chloride channel
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- intracellular space
- Nucleus
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ano7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- anchoring junction
- cytosol
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- intracellular calcium activated chloride channel activity
- protein dimerization activity
- chloride channel activity