ANO7 Gene Summary [Human]

This prostate-specific gene encodes a cytoplasmic protein, as well as a polytopic membrane protein which may serve as a target in prostate cancer diagnosis and immunotherapy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2011]

Details

Type
Protein Coding
Official Symbol
ANO7
Official Name
anoctamin 7 [Source:HGNC Symbol;Acc:HGNC:31677]
Ensembl ID
ENSG00000146205
Bio databases IDs NCBI: 50636 Ensembl: ENSG00000146205
Aliases anoctamin 7
Synonyms anoctamin 7, D-TMPP, Gm598, IPCA-5, LOC108352008, NGEP, Ngep-L, PCANAP5, PCANAP5L, TMEM16G
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ANO7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Calcium-activated chloride channel
  • phospholipid scramblase
  • dimerization domain of Ca+-activated chloride-channel, anoctamin
  • chloride channel
  • intracellular calcium activated chloride channel
  • transporter

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • epithelial cancer
  • lung adenocarcinoma
  • lung adenocarcinoma formation
  • prostatic carcinoma
  • prostate cancer
  • neuroblastoma
  • neuroblastoma formation
regulates
  • ion
  • chloride
role in cell
  • aggregation

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • Cytoplasm
  • intracellular space
  • Nucleus
  • Endoplasmic Reticulum

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human ANO7 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • ion transmembrane transport

Cellular Component

Where in the cell the gene product is active
  • anchoring junction
  • cytosol
  • endoplasmic reticulum
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • intracellular calcium activated chloride channel activity
  • protein dimerization activity
  • chloride channel activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.