Cfap74 Gene Summary [Rat]
Predicted to be located in cytoplasm; nucleus; and sperm flagellum. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human CFAP74 (cilia and flagella associated protein 74). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cfap74 |
| Official Name | cilia and flagella associated protein 74 [Source:RGD Symbol;Acc:2324110] |
| Ensembl ID | ENSRNOG00000023627 |
| Bio databases IDs | |
| Aliases | cilia and flagella associated protein 74 |
| Synonyms | 2010015L04Rik, A530045M11, C1orf222, CILD49, cilia and flagella associated protein 74, KIAA1751, LOC728690 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cfap74 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain of unknown function (DUF4659)
- Coiled-coil domain-containing protein 3
- Trichohyalin-plectin-homology domain
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- axonemes
- sperm tail
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cfap74 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- axoneme assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- sperm flagellum
- axoneme