Spindoc Gene Summary [Rat]
Predicted to be involved in DNA damage response and negative regulation of DNA-templated transcription. Predicted to be active in nucleus and site of DNA damage. Orthologous to human SPINDOC (spindlin interactor and repressor of chromatin binding). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spindoc |
| Official Name | spindlin interactor and repressor of chromatin binding [Source:RGD Symbol;Acc:1308106] |
| Ensembl ID | ENSRNOG00000025061 |
| Bio databases IDs | |
| Aliases | spindlin interactor and repressor of chromatin binding |
| Synonyms | 1700105P06Rik, C11orf84, LOC144097, RGD1308106, spindlin interactor and repressor of chromatin binding |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Spindoc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain of unknown function (DUF4371)
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Spindoc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- regulation of protein ADP-ribosylation
- response to DNA damage stimulus
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- protein binding