C1qtnf1 Gene Summary [Rat]
Predicted to enable collagen binding activity and identical protein binding activity. Predicted to be involved in several processes, including negative regulation of platelet aggregation; positive regulation of aldosterone secretion; and positive regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within positive regulation of MAPK cascade; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and regulation of glucose metabolic process. Predicted to be located in plasma membrane. Predicted to be part of collagen trimer. Predicted to be active in extracellular space. Orthologous to human C1QTNF1 (C1q and TNF related 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | C1qtnf1 |
| Official Name | C1q and TNF related 1 [Source:RGD Symbol;Acc:1359204] |
| Ensembl ID | ENSRNOG00000003259 |
| Bio databases IDs | |
| Aliases | C1q and TNF related 1 |
| Synonyms | 1600017K21Rik, Adip, C1q and TNF related 1, C1q and tumor necrosis factor related protein 1, C1q and tumour necrosis factor related protein 1, Complement-C1q and Tumor Necrosis Factor Related Protein 1, Complement-C1q and tumour Necrosis Factor Related Protein 1, CTRP1, GIP, ZSIG37 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat C1qtnf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- collagen binding
- Collagen triple helix repeat (20 copies)
- protein binding
- identical protein binding
- C1q domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- renal clear cell adenocarcinoma
- obesity
- organismal death
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- left ventricular dysfunction
- angioimmunoblastic T-cell lymphoma
- renal clear cell cancer
- weight gain
role in cell
- expression in
- production in
- proliferation
- phosphorylation in
- binding in
- migration
- invasion by
- apoptosis
- cellular infiltration by
- aggregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat C1qtnf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of glucose metabolic process
- positive regulation of gene expression
- negative regulation of platelet aggregation
- negative regulation of platelet activation
- positive regulation of MAPK cascade
- positive regulation of protein kinase B signaling cascade
- positive regulation of aldosterone secretion
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- collagen
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- collagen binding