Zfp292 Gene Summary [Rat]
Enables DNA binding activity and DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 64. Orthologous to human ZNF292 (zinc finger protein 292). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zfp292 |
| Official Name | zinc finger protein 292 [Source:RGD Symbol;Acc:61931] |
| Ensembl ID | ENSRNOG00000031031 |
| Bio databases IDs | |
| Aliases | zinc finger protein 292 |
| Synonyms | 5730450D02Rik, 5830493J20Rik, 9430062L07Rik, bA393I2.3, Krox-10, mKIAA0530, MRD63, MRD64, Nbla00365, ZFP15, ZFP292, zinc finger protein 292, Zn-15, ZN-16 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Zfp292 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autism
- hereditary disorder
- neurodevelopmental disorder
- autosomal dominant mental retardation type 64
- mental retardation
- Alzheimer disease
- atrial fibrillation
- complex neurodevelopmental disorder
- infection by HIV-1
regulates
- RNA polymerase II
- DNA promoter
- DNA endogenous promoter
role in cell
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Zfp292 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- DNA binding
- metal ion binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity