Slc17a3 Gene Summary [Rat]
Predicted to enable several functions, including toxin transmembrane transporter activity; urate transmembrane transporter activity; and voltage-gated monoatomic anion channel activity. Predicted to be involved in urate metabolic process; urate transport; and xenobiotic detoxification by transmembrane export across the plasma membrane. Predicted to be located in endoplasmic reticulum membrane; perinuclear region of cytoplasm; and plasma membrane. Predicted to be active in apical plasma membrane. Human ortholog(s) of this gene implicated in gout. Orthologous to human SLC17A3 (solute carrier family 17 member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc17a3 |
| Official Name | solute carrier family 17 member 3 [Source:RGD Symbol;Acc:628815] |
| Ensembl ID | ENSRNOG00000032745 |
| Bio databases IDs | |
| Aliases | solute carrier family 17 member 3 |
| Synonyms | AW261723, GOUT4, NPT4, RNPT4, solute carrier family 17 member 3, solute carrier family 17 (sodium phosphate), member 3, UAQTL4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc17a3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphoglycerate transporter family protein
- efflux permease
- xenobiotic transporter
- Multidrug resistance protein
- Major Facilitator Superfamily
- voltage-dependent ion-selective channel
- toxin transporter
- Na(+)-dependent inorganic phosphate cotransporter
- organic anion transporter
- sodium:phosphate symporter
- urate transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
- systemic lupus erythematosus
- gout susceptibility 4
- breast carcinoma
- schizophrenia
- insulin-dependent diabetes mellitus
- hypercholesterolemia
- estrogen receptor positive breast cancer
regulates
- phosphate
- uric acid
- glucose-6-phosphate
- Na+
- organic anion
- ion
- homocysteine
role in cell
- invasion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- perinuclear region
- cellular membrane
- endoplasmic reticulum membrane
- apical membrane
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc17a3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sodium ion transport
- glucose-6-phosphate transport
- phosphate ion transport
- ion transmembrane transport
- sodium ion transmembrane transport
- urate transport
- anion transport
- urate metabolic process
- organic anion transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- perinuclear region of cytoplasm
- brush border membrane
- cytoplasm
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- xenobiotic transporter activity
- sodium:phosphate symporter activity
- voltage-gated anion channel activity
- efflux transmembrane transporter activity
- urate transmembrane transporter activity
- toxin transporter activity
- organic anion transmembrane transporter activity