Marc2 Gene Summary [Rat]
Predicted to enable molybdenum ion binding activity; molybdopterin cofactor binding activity; and oxidoreductase activity, acting on other nitrogenous compounds as donors. Predicted to contribute to nitrite reductase (NO-forming) activity. Predicted to be involved in cellular detoxification of nitrogen compound; nitrate metabolic process; and nitric oxide biosynthetic process. Predicted to be located in mitochondrion. Predicted to be part of nitric-oxide synthase complex. Orthologous to human MTARC1 (mitochondrial amidoxime reducing component 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Marc2 |
| Official Name | mitochondrial amidoxime reducing component 2 [Source:RGD Symbol;Acc:621257] |
| Ensembl ID | ENSRNOG00000037850 |
| Bio databases IDs | |
| Aliases | mitochondrial amidoxime reducing component 2 |
| Synonyms | 2810484M10Rik, LOC364084, mARC1, MARC2, Mg87, mitochondrial amidoxime reducing component 2, MOSC2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Marc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MOSC domain
- molybdenum ion binding
- binding protein
- nitrate reductase
- MOSC N-terminal beta barrel domain
- enzyme
- nitrogenous compound oxidoreductase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- acute graft-vs-host disease
regulates
- nitric oxide
- lipid
- D-glucose
- cholesterol
- benzamidine
- benzamidoxime
- Mtarc1
- nitrate
role in cell
- apoptosis
- synthesis in
- reduction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Marc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- detoxification of nitrogen compound
- nitric oxide biosynthetic process
- nitrate metabolic process
- cellular detoxification of nitrogen compound
Cellular Component
Where in the cell the gene product is active
- peroxisome
- mitochondrion
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- pyridoxal phosphate binding
- molybdenum ion binding
- nitrate reductase activity
- oxidoreductase activity, acting on other nitrogenous compounds as donors
- molybdopterin cofactor binding