Neurog1 Gene Summary [Rat]
Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including cochlea morphogenesis; nervous system development; and regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including inner ear morphogenesis; positive regulation of exit from mitosis; and regulation of neuron differentiation. Predicted to be located in perikaryon. Predicted to be active in nucleus. Orthologous to human NEUROG1 (neurogenin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Neurog1 |
| Official Name | neurogenin 1 [Source:RGD Symbol;Acc:3167] |
| Ensembl ID | ENSRNOG00000022405 |
| Bio databases IDs | |
| Aliases | neurogenin 1 |
| Synonyms | AKA, bHLHa6, CCDDRD, Math4C, NEUROD3, neurogenin 1, Ngn1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Neurog1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- DNA binding domain
- nucleic acid binding
- basic Helix Loop Helix (bHLH) domain superfamily
- chromatin binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- helix loop helix domain
- protein homodimerization
- Helix-loop-helix DNA-binding domain
- basic domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the Neurog1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- congenital cranial dysinnervation disorder with absent corneal reflex and developmental delay
role in cell
- expression in
- survival
- migration
- quantity
- generation
- differentiation
- development
- formation
- misspecification
- modification
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Neurog1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inner ear development
- trigeminal nerve development
- nervous system development
- positive regulation of neuron differentiation
- thorax and anterior abdomen determination
- regulation of muscle organ development
- craniofacial suture morphogenesis
- vestibulocochlear nerve formation
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of exit from mitosis
- forebrain development
- exit from mitosis
- genitalia morphogenesis
- genitalia development
- cochlea development
- cochlea morphogenesis
- sensory organ development
- regulation of transcription from RNA polymerase II promoter
- inner ear morphogenesis
- cell fate commitment
- auditory behavior
- mastication
- peristalsis
- neuromuscular process controlling balance
Cellular Component
Where in the cell the gene product is active
- nucleus
- perikaryon
- chromatin
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- protein homodimerization activity
- chromatin binding
- E-box binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity