Pigk Gene Summary [Rat]
Predicted to enable GPI-anchor transamidase activity. Predicted to be involved in GPI anchor biosynthetic process; attachment of GPI anchor to protein; and proteolysis. Predicted to be part of GPI-anchor transamidase complex. Orthologous to human PIGK (phosphatidylinositol glycan anchor biosynthesis class K). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pigk |
| Official Name | phosphatidylinositol glycan anchor biosynthesis, class K [Source:RGD Symbol;Acc:1306753] |
| Ensembl ID | ENSRNOG00000042359 |
| Bio databases IDs | |
| Aliases | phosphatidylinositol glycan anchor biosynthesis, class K |
| Synonyms | 3000001O05Rik, Gm38470, GPI8, NEDHCAS, phosphatidylinositol glycan anchor biosynthesis class K, phosphatidylinositol glycan anchor biosynthesis, class K |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pigk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CASc
- lipid binding
- binding protein
- GPI-anchor transamidase
- peptidase
- protein binding
- phosphatidylinositol binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neurodevelopmental disorder with hypotonia and cerebellar atrophy without seizures
- neurodevelopmental disorder with hypotonia and cerebellar atrophy with or without seizures
- neurodevelopmental disorder with hypotonia and cerebellar atrophy with seizures
- infection by HIV-1
regulates
- ALPP
- glycosylphosphatidylinositol
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- mitochondria-associated membranes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pigk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- attachment of GPI anchor to protein
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- GPI-anchor transamidase complex
Molecular Function
What the gene product does at the molecular level
- protein disulfide isomerase activity
- protein binding
- GPI-anchor transamidase activity
- GPI anchor binding