Gp9 Gene Summary [Rat]
Predicted to be involved in several processes, including blood coagulation, intrinsic pathway; megakaryocyte development; and positive regulation of platelet activation. Predicted to be part of glycoprotein Ib-IX-V complex. Human ortholog(s) of this gene implicated in Bernard-Soulier syndrome. Orthologous to human GP9 (glycoprotein IX platelet). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gp9 |
| Official Name | glycoprotein IX (platelet) [Source:RGD Symbol;Acc:1561601] |
| Ensembl ID | ENSRNOG00000010015 |
| Bio databases IDs | |
| Aliases | glycoprotein IX (platelet) |
| Synonyms | CD42, CD42a, glycoprotein 9 platelet, glycoprotein IX platelet, glycoprotein IX (platelet), GPIX |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gp9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine rich repeat C-terminal domain
- protein binding
- Leucine rich repeat N-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Bernard-Soulier syndrome type C
- primary hyperaldosteronism
- Bernard-Soulier syndrome
- pemphigus vulgaris
- essential thrombocythemia
- type M7 acute myeloid leukemia
role in cell
- binding
- phosphorylation in
- adhesion
- cell rolling
- activation
- production in
- autophagy
- autophagy in
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gp9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of platelet activation
- megakaryocyte development
- blood coagulation, intrinsic pathway
- cell adhesion
- release of sequestered calcium ion into cytosol
- blood coagulation
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding