Chst14 Gene Summary [Rat]
This gene encodes a member of the HNK-1 family of sulfotransferases. The encoded protein transfers sulfate to the C-4 hydroxyl of N-acetylgalactosamine residues in dermatan sulfate. Mutations in this gene have been associated with adducted thumb-clubfoot syndrome.[provided by RefSeq, Mar 2010]
Details
| Type | Protein Coding |
| Official Symbol | Chst14 |
| Official Name | carbohydrate sulfotransferase 14 [Source:RGD Symbol;Acc:1585023] |
| Ensembl ID | ENSRNOG00000045997 |
| Bio databases IDs | |
| Aliases | carbohydrate sulfotransferase 14 |
| Synonyms | 2600016L03Rik, ATCS, carbohydrate sulfotransferase 14, carbohydrate sulphotransferase 14, D4ST-1, EDSMC1, HNK1ST, LOC687718 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Chst14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- dermatan 4-sulfotransferase
- N-acetylgalactosamine-4-O-sulfotransferase
- enzyme
- protein binding
- Sulfotransferase family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- musculocontractural Ehlers-Danlos syndrome type 1
- musculocontractural type Ehlers-Danlos syndrome
- thoracic kyphosis
- productive infection by HIV-1
regulates
- N-acetyl-D-galactosamine
- chondroitin sulfate B proteoglycan
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Chst14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- dermatan sulfate biosynthetic process
- carbohydrate biosynthetic process
- dermatan sulfate proteoglycan metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- N-acetylgalactosamine 4-O-sulfotransferase activity
- sulfotransferase activity
- phosphate ion binding