Asap3 Gene Summary [Rat]
Predicted to enable GTPase activator activity. Predicted to be involved in cell migration; positive regulation of GTPase activity; and regulation of stress fiber assembly. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in focal adhesion; intracellular membrane-bounded organelle; and ruffle. Orthologous to human ASAP3 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Asap3 |
| Official Name | ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 [Source:RGD Symbol;Acc:1593929] |
| Ensembl ID | ENSRNOG00000049714 |
| Bio databases IDs | |
| Aliases | ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 |
| Synonyms | 9430088F20Rik, ACAP4, ArfGAP with SH3 domain, ankyrin repeat and PH domain 3, CENTB6, DDEFL1, Gm140, UPLC1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Asap3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ankyrin repeats (many copies)
- Putative GTP-ase activating proteins for the small GTPase, ARF
- Ankyrin repeats (3 copies)
- PH domain
- GTPase activator
- protein binding
- Pleckstrin homology-like domain
- Metaviral_G glycoprotein
- GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
- Bin/Amphiphysin/Rvs domain
- Putative GTPase activating protein for Arf
- Ankyrin repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- systemic lupus erythematosus
- colorectal adenoma
- colorectal adenoma formation
regulates
- GTPase
role in cell
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- ruffle
- focal adhesions
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Asap3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of stress fiber assembly
- cell migration
- positive regulation of GTPase activity
Cellular Component
Where in the cell the gene product is active
- focal adhesion
- intracellular membrane-bounded organelle
- ruffle
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- GTPase activator activity