Gdf10 Gene Summary [Rat]
Predicted to enable cytokine activity. Involved in several processes, including positive regulation of osteoblast differentiation; response to kainic acid; and response to transforming growth factor beta. Located in extracellular space. Orthologous to human GDF10 (growth differentiation factor 10). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gdf10 |
| Official Name | growth differentiation factor 10 [Source:RGD Symbol;Acc:621512] |
| Ensembl ID | ENSRNOG00000051993 |
| Bio databases IDs | |
| Aliases | growth differentiation factor 10 |
| Synonyms | BIP, BMP-3b, growth differentiation factor 10 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gdf10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TGF_beta_SF
- Transforming growth factor beta like domain
- growth factor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- neoplasia
- vascular calcification
- epithelial thyroid cancer
- anaplastic thyroid carcinoma
- anaplastic thyroid cancer
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
- uterine serous papillary cancer
role in cell
- expression in
- differentiation
- ossification by
- deposition in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gdf10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- skeletal system development
- cerebellum development
- transforming growth factor beta receptor signaling pathway
- osteoblast differentiation
- fat cell differentiation
- positive regulation of osteoblast differentiation
- regulation of ossification
- ovulation cycle
Cellular Component
Where in the cell the gene product is active
- extracellular space
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- cytokine activity