Smad2 Gene Summary [Rat]
Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; SMAD binding activity; and enzyme binding activity. Predicted to contribute to DNA binding activity and DNA-binding transcription factor activity. Involved in several processes, including cell surface receptor protein serine/threonine kinase signaling pathway; cellular response to glucose stimulus; and regulation of gene expression. Part of protein-containing complex. Used to study hepatocellular carcinoma. Biomarker of colon cancer and myocardial infarction. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 6; Lynch syndrome; cervical cancer; and ovarian cancer. Orthologous to human SMAD2 (SMAD family member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Smad2 |
| Official Name | SMAD family member 2 [Source:RGD Symbol;Acc:3031] |
| Ensembl ID | ENSRNOG00000018140 |
| Bio databases IDs | |
| Aliases | SMAD family member 2 |
| Synonyms | 7120426M23RIK, CHTD8, hMAD-2, hSMAD2, JV18, JV18-1, LDS6, MADH2, MADR2, mMad2, SMAD family member 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Smad2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SMAD binding
- transcription regulator
- mad homology domain 1
- SSXS motif
- transcription factor binding
- chromatin binding
- identical protein binding
- N-terminal Mad Homology 1 (MH1) domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- tau protein binding
- MH1 domain
- C-terminal Mad Homology 2 (MH2) domain
- phosphatase binding
- ubiquitin protein ligase binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- MH2 domain
- SSMS domain
- MH domain
- nucleic acid binding
- PPXY motif
- linker domain
- protein domain specific binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- phosphorylation site
- Erk1/2 phosphorylation site
- double-stranded DNA binding
- transforming growth factor-beta receptor binding
- transcription factor activity
Pathways
Biological processes and signaling networks where the Smad2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Antiproliferative Role of TOB in T Cell Signaling
- Colorectal Cancer Metastasis Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- GADD45 Signaling
- Glucocorticoid Receptor Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- HIPPO signaling
- Human Embryonic Stem Cell Pluripotency
- Iron homeostasis signaling pathway
- Molecular Mechanisms of Cancer
- Osteoarthritis Pathway
- Pancreatic Adenocarcinoma Signaling
- PPARα/RXRα Activation
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- SPINK1 Pancreatic Cancer Pathway
- TGF-β Signaling
- Transcriptional Regulatory Network in Embryonic Stem Cells
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastatic colon cancer
- colorectal cancer
- epithelial cancer
- epithelial neoplasia
- cancer
- non-small cell lung cancer
- lung squamous cell carcinoma
- squamous cell lung cancer
- metastatic breast cancer
role in cell
- expression in
- proliferation
- phosphorylation in
- migration
- apoptosis
- survival
- cell viability
- formation
- quantity
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular membrane-bounded organelle
- Cytoplasm
- cytosol
- caveolar membranes
- nucleoplasm
- nuclear speckles
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Smad2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- organ growth
- insulin secretion
- zygotic specification of dorsal/ventral axis
- negative regulation of cell proliferation
- post-embryonic development
- anterior/posterior pattern specification
- transforming growth factor beta receptor signaling pathway
- signal transduction involved in regulation of gene expression
- anatomical structure morphogenesis
- positive regulation of transcription from RNA polymerase II promoter
- embryonic foregut morphogenesis
- nodal signaling pathway
- positive regulation of epithelial to mesenchymal transition
- activin receptor signaling pathway
- endocardial cushion morphogenesis
- paraxial mesoderm morphogenesis
- negative regulation of transcription, DNA-dependent
- cellular response to glucose stimulus
- positive regulation of transcription, DNA-dependent
- in utero embryonic development
- endoderm formation
- odontoblast differentiation
- mesoderm formation
- intracellular signal transduction
- adrenal gland development
- response to cholesterol
- lung development
- pancreas development
- aortic valve morphogenesis
- primary miRNA processing
- transcription, DNA-dependent
- SMAD protein signal transduction
- pulmonary valve morphogenesis
- determination of left/right asymmetry in lateral mesoderm
- embryonic cranial skeleton morphogenesis
- regulation of transcription, DNA-dependent
- pericardium development
- gastrulation
- positive regulation of BMP signaling pathway
- ureteric bud development
- positive regulation of gene expression
- regulation of binding
- cell fate commitment
- cell differentiation
- regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- SMAD protein complex
- SMAD2 protein complex
- transcription factor complex
- nucleus
- cytoplasm
- SMAD2-SMAD3 protein complex
- activin responsive factor complex
- cytosol
- macromolecular complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- phosphatase binding
- identical protein binding
- transforming growth factor beta receptor binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- double-stranded DNA binding
- core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- ubiquitin protein ligase binding
- SMAD binding
- metal ion binding
- tau protein binding
- R-SMAD binding
- co-SMAD binding
- I-SMAD binding
- type I transforming growth factor beta receptor binding