Hephl1 Gene Summary [Rat]
Predicted to enable ferroxidase activity. Predicted to be involved in intracellular iron ion homeostasis. Predicted to be active in plasma membrane. Orthologous to human HEPHL1 (hephaestin like 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hephl1 |
| Official Name | hephaestin-like 1 [Source:RGD Symbol;Acc:1564835] |
| Ensembl ID | ENSRNOG00000056092 |
| Bio databases IDs | |
| Aliases | hephaestin-like 1 |
| Synonyms | cw, Gm509, hephaestin-like 1, HJDD, RGD1564835, thd, ZP, zyklopen |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hephl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Multicopper oxidase
- Cupredoxin superfamily
- enzyme
- ferroxidase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hephl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular iron ion homeostasis
- copper ion transport
- iron ion transport
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- copper ion binding
- ferroxidase activity