Vti1b Gene Summary [Rat]
Predicted to enable SNAP receptor activity; SNARE binding activity; and chloride channel inhibitor activity. Predicted to be involved in several processes, including Golgi vesicle transport; regulation of protein localization to plasma membrane; and retrograde transport, endosome to Golgi. Located in neuronal cell body and synaptic vesicle. Part of SNARE complex. Is active in presynaptic endosome membrane. Orthologous to human VTI1B (vesicle transport through interaction with t-SNAREs 1B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vti1b |
| Official Name | vesicle transport through interaction with t-SNAREs 1B [Source:RGD Symbol;Acc:2323682] |
| Ensembl ID | ENSRNOG00000060436 |
| Bio databases IDs | |
| Aliases | vesicle transport through interaction with t-SNAREs 1B |
| Synonyms | GES30, MVti1b, RGD1560475, SNARE, T-snares 1b hmlg, Vesicle transport through interactin with t-snares 1b homolog, vesicle transport through interaction with t-SNAREs 1B, v-SNARE, VTI1, VTI1L, Vti1l1, VTI1-LIKE, Vti1-rp1, VTI2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Vti1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- Vesicle transport v-SNARE protein N-terminus
- Helical region found in SNAREs
- Snare region anchored in the vesicle membrane C-terminus
- protein binding
- SNARE motif
- chloride channel inhibitor activity
- transporter
Pathways
Biological processes and signaling networks where the Vti1b gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypoplasia
- neurodegeneration
- essential thrombocythemia
role in cell
- apoptosis
- accumulation
- function
- activity
- abnormal morphology
- fusion
- docking
- outgrowth
- tethering
- guidance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Golgi-enriched fraction
- intracellular membrane-bounded organelle
- Extracellular Space
- perinuclear region
- cellular membrane
- Nucleus
- endosomes
- vesicles
- Golgi Apparatus
- granules
- trans Golgi network
- lysosome membrane
- endosomal membrane
- alpha granules
- synaptic vesicles
- recycling endosomes
- perikaryon
- clathrin-coated vesicles
- medial Golgi cisternae
- cis Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Vti1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane fusion
- vesicle-mediated transport
- vesicle docking involved in exocytosis
- intra-Golgi vesicle-mediated transport
- retrograde transport, endosome to Golgi
- intracellular protein transport
- macroautophagy
- vesicle fusion with Golgi apparatus
- Golgi to vacuole transport
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule lumen
- synaptic vesicle
- Golgi apparatus
- neuronal cell body
- extracellular region
- lysosomal membrane
- early endosome membrane
- endoplasmic reticulum membrane
- late endosome membrane
- perinuclear region of cytoplasm
- intracellular membrane-bounded organelle
- ER to Golgi transport vesicle membrane
- cytosol
- vesicle
- SNARE complex
- recycling endosome
- recycling endosome membrane
Molecular Function
What the gene product does at the molecular level
- chloride channel inhibitor activity
- protein binding
- SNAP receptor activity
- SNARE binding