Epb41l4b Gene Summary [Rat]
Predicted to enable cytoskeletal protein binding activity. Predicted to be involved in several processes, including actomyosin structure organization; positive regulation of keratinocyte migration; and wound healing. Predicted to be located in apical part of cell; cytosol; and plasma membrane. Predicted to be active in cytoskeleton. Orthologous to human EPB41L4B (erythrocyte membrane protein band 4.1 like 4B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Epb41l4b |
| Official Name | erythrocyte membrane protein band 4.1 like 4B [Source:RGD Symbol;Acc:1562988] |
| Ensembl ID | ENSRNOG00000056550 |
| Bio databases IDs | |
| Aliases | erythrocyte membrane protein band 4.1 like 4B |
| Synonyms | 6430543G08RIK, CG1, D4Ertd346e, EHM2, Epb4.1l4b, erythrocyte membrane protein band 4.1 like 4B, FLJ21596, LULU2, RGD1562988 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Epb41l4b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FERM adjacent (FA)
- FERM central domain
- Band 4.1 homologues
- structural constituent of cytoskeleton
- Ubl1_cv_Nsp3_N-like
- protein binding
- Pleckstrin homology-like domain
- FERM domain B-lobe
- FERM C-terminal PH-like domain
- transporter
- FERM N-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- liver cancer
- epithelial cancer
- metabolic syndrome X
- hepatocellular carcinoma
- peripheral arterial disease
- non-small cell lung cancer
- non-small cell lung carcinoma
- coronary thrombosis
role in cell
- adhesion
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoskeleton
- apical compartment
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Epb41l4b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- wound healing
- actomyosin structure organization
- positive regulation of gene expression
- regulation of keratinocyte proliferation
- positive regulation of keratinocyte migration
- positive regulation of cell adhesion
Cellular Component
Where in the cell the gene product is active
- tight junction
- cytoskeleton
- apical part of cell
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- structural constituent of cytoskeleton
- cytoskeletal protein binding