S100a8 Gene Summary [Rat]
Predicted to enable calcium ion binding activity and calcium-dependent protein binding activity. Involved in several processes, including autocrine signaling; response to ethanol; and response to lipopolysaccharide. Located in extracellular space. Biomarker of urinary bladder cancer. Human ortholog(s) of this gene implicated in myocarditis. Orthologous to human S100A8 (S100 calcium binding protein A8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | S100a8 |
| Official Name | S100 calcium binding protein A8 [Source:RGD Symbol;Acc:620265] |
| Ensembl ID | ENSRNOG00000011557 |
| Bio databases IDs | |
| Aliases | S100 calcium binding protein A8 |
| Synonyms | 60B8AG, B8Ag, CAGA, calgranulin A, CALPROTECTIN, CFAG, CGLA, CP-10, CYSTIC FIBROSIS ANTIGEN, L1Ag, MA387, MIF, MIGRATION INHIBITORY FACTOR RELATED protein 8, MRP8, NIF, P8, PM-2K, S100 calcium binding protein A8, S100 calcium binding protein A8 (calgranulin A) |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat S100a8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- EF-hand, calcium binding motif
- S-100/ICaBP type calcium binding domain
- zinc ion binding
- EF hand
- EF-hand domain pair
- calcium ion binding
- EFh
- arachidonic acid binding
- protein binding
- receptor binding
Pathways
Biological processes and signaling networks where the S100a8 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- Crohn disease
- ulcerative colitis
- COVID-19
- epithelial cancer
- papillomatosis
- breast adenocarcinoma
- sepsis
- liver cancer
- hepatocellular carcinoma
role in cell
- cell death
- migration
- expression in
- cell viability
- apoptosis
- activation in
- degradation in
- formation
- formation in
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intermediate filament cytoskeleton
- secretory granule lumen
- cytoskeleton
- Extracellular Space
- Nucleus
- Plasma Membrane
- cytosol
- nucleoli
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat S100a8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- astrocyte development
- response to zinc ion
- positive regulation of NF-kappaB transcription factor activity
- response to ethanol
- positive regulation of cell growth
- inflammatory response
- autophagy
- apoptotic process
- neutrophil aggregation
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- defense response to fungus
- positive regulation of intrinsic apoptotic signaling pathway
- peptidyl-cysteine S-nitrosylation
- regulation of toll-like receptor signaling pathway
- positive regulation of inflammatory response
- peptide secretion
- positive regulation of peptide secretion
- defense response to bacterium
- chronic inflammatory response
- sequestering of zinc ion
- leukocyte migration involved in inflammatory response
- regulation of cytoskeleton organization
- innate immune response
- neutrophil chemotaxis
- response to lipopolysaccharide
- autocrine signaling
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- cytoskeleton
- extracellular vesicular exosome
- intermediate filament cytoskeleton
- cytosol
- secretory granule lumen
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- Toll-like receptor 4 binding
- zinc ion binding
- protein binding
- calcium ion binding
- calcium-dependent protein binding
- RAGE receptor binding
- arachidonic acid binding
- microtubule binding