Antisense LNA GapmeRs

For highly effective knockdown of mRNA and lncRNA using LNA-enhanced antisense oligonucleotides

Function by RNase H-dependent degradation of complementary RNA targets

Provide strand-specific knockdown with no RISC-associated off-target activity

Active in vivo and in vitro, enabling the analysis RNA function in a wide range of model systems

Excellent alternative to siRNA for knockdown of mRNA and lncRNA

Taken up by cells without need for transfection reagents

Variety of controls support transfection or unassisted uptake protocol optimization