Target List
Adenocarcinomas
ABL1, AKT1, ALK, ATM, BRAF, CCND1, CD274 (PD-L1), CD274 (PD-L1), CDK4, CDKN2A (P16INK4A), CTNNB1, DDR2, EGFR (ERBB1), ERBB2 (HER-2, NEU), FGFR1, FGFR3, HRAS, KRAS, MAP2K1, MAP3K8, MET, MYC, MYCN, NRAS, NTRK1, PIK3CA (p110-alpha), PPP2R1B, PRKN, PTEN, RET, ROS1, SLC22A18, STK11 (LKB1), TP53 (p53), TSC2
Malignant Pleural Mesotheliomas
BAP1, NF2
Non-Small Cell Lung Cancers (NSCLC)
AKT1, ALK, ATM, BARD1, BRAF, BRCA1, BRCA2, BRIP1, CCND1, CDK12, CDK4, CDKN2A (P16INK4A), CHEK1, CHEK2 (RAD53), CTNNB1, EGFR (ERBB1), ERBB2 (HER-2, NEU), FANCL, FGFR3, HRAS, IDH1, IRF1, KIT (CD117), KRAS, MAP2K1, MET, MLH1, MLH3, MSH2, MSH3, MSH6, MYC, NRAS, PALB2, PDGFRA, PIK3CA (p110-alpha), PMS1, PMS2, PTEN, RAD51B, RAD51C, RAD51D, RAD54L, RET, ROS1, TP53 (p53)
Small Cell Lung Cancers (SCLC)
CD274 (PD-L1), CD274 (PD-L1), HRAS, MYC, MYCN, NTRK1, PIK3CA (p110-alpha), PPP2R1B, PTEN, RB1, TP53 (p53)
Squamous Cell Carcinomas
BRAF, CD274 (PD-L1), CD274 (PD-L1), CDKN2A (P16INK4A), DDR2, EGFR (ERBB1), FGFR1, FGFR3, HRAS, MAP3K8, MYC, MYCN, NTRK1, PIK3CA (p110-alpha), PPP2R1B, PTEN, SLC22A18, TP53 (p53), TSC2