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Non-Small Cell Lung Cancer Signaling

Non-small cell lung cancer (NSCLC) accounts for approximately 80% of lung cancers. It represents a heterogeneous group of cancers consisting mainly of squamous cell, adeno and large-cell carcinoma. Genetic alterations seen in NSCLC include activation of oncogenes or the inactivation of tumor suppressor genes. Mutations in the K-Ras oncogene inactivate GTPase activity, leading to a continuous transmition of growth signals to the nucleus. K-Ras mutations also affect the PI3K/AKT and Ras/Raf/ERK signaling pathways resulting in uncontrolled cell proliferation and inhibition of apoptosis...

Non-Small Cell Lung Cancer Signaling

Pathway Summary

Non-small cell lung cancer (NSCLC) accounts for approximately 80% of lung cancers. It represents a heterogeneous group of cancers consisting mainly of squamous cell, adeno and large-cell carcinoma. Genetic alterations seen in NSCLC include activation of oncogenes or the inactivation of tumor suppressor genes. Mutations in the K-Ras oncogene inactivate GTPase activity, leading to a continuous transmition of growth signals to the nucleus. K-Ras mutations also affect the PI3K/AKT and Ras/Raf/ERK signaling pathways resulting in uncontrolled cell proliferation and inhibition of apoptosis.Tumor suppressor genes that are inactivated include p53, RASSF1, p16INK4a, FHIT and retinoic acid receptor (RAR)-β. Loss of p16INK4a interferes with the cell cycle while inactivation of p53 results in rapid cellular proliferation and reduced apoptotic signals. RASSF1A forms heterodimers with Nore-1, a RAS effector. Loss of RASSF1A shifts RAS signaling towards growth promoting activity.Retinoic acid plays an important role in lung development and differentiation, acting primarily via the RAR-β gene. Promoter methylation and silencing of the RAR-β gene is frequently seen in SCLC. Overexpression of c-erbB-2 or EGFR leads to a proliferative advantage via the PI3K/AKT and Ras/Raf/ERK signaling pathways.

Non-Small Cell Lung Cancer Signaling Genes list

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Products related to Non-Small Cell Lung Cancer Signaling

Explore products related to Non-Small Cell Lung Cancer Signaling
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GeneGlobe ID: UPHS-134Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
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GeneGlobe ID: UPHS-033Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
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GeneGlobe ID: JHS-002Z | Cat. No.: | QIAseq RNA Fusion XP Panels
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GeneGlobe ID: SBHS-033Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
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GeneGlobe ID: JHS-003Z | Cat. No.: | QIAseq RNA Fusion XP Panels
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GeneGlobe ID: PHS-005Z | Cat. No.: | QIAseq Targeted DNA Pro Panels
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GeneGlobe ID: PHS-3000Z | Cat. No.: | QIAseq Targeted DNA Pro Panels
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GeneGlobe ID: YHS-005Z | Cat. No.: | QIAseq Targeted cfDNA Ultra Panels
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GeneGlobe ID: PHS-3100Z | Cat. No.: | QIAseq Targeted DNA Pro Panels
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GeneGlobe ID: PAHS-033Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
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GeneGlobe ID: PAHS-134Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
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GeneGlobe ID: PHS-105Z | Cat. No.: | QIAseq Targeted DNA Pro Panels
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