GeneGlobe ID: SBHS-050Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels

QuantiNova LNA PCR Focus Panel Human Cellular Senescence

QuantiNova LNA PCR Focus Panel
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Product Specification

Target List
Senescence Pathway
ATM, BMI1, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A (p21CIP1, WAF1), CDKN2A (P16INK4A), CDKN2D (p19-INK4D), CHEK1, CHEK2 (RAD53), E2F1, E2F3, ETS1, ETS2, MDM2, RB1, RBL2, TP53 (p53), TWIST1
Senescence Initiators
p53 Signaling​
ABL1
p53 / pRb Signaling & the Cell Cycle​
AKT1, ALDH1A3 (RALDH3), CCNA2, CCNB1, CDC25C, CDKN1C (p57Kip2), CDKN2B (p15INK4b), CDKN2C (p18-INK4C), CITED2, CREG1, GSK3B, ID1, IGF1R, IGFBP3, ING1, MAP2K6 (MEK6, MKK6), MAPK14 (p38ALPHA), MORC3, MYC, PCNA, PIK3CA (p110-alpha), PLAU (UPA), RBL1, SERPINB2 (PAI-2), SERPINE1 (PAI-1), SIRT1, SPARC, TGFB1
Interferon Signaling​
ALDH1A3 (RALDH3), CDKN1A (p21CIP1, WAF1), CDKN1B (P27KIP1), EGR1, IFNG, IGFBP3, IGFBP7, IRF3, IRF5, IRF7, NFKB1, RB1, SERPINB2 (PAI-2)
Insulin Growth Factor (IGF) Related​
IGF1, IGF1R, IGFBP3, IGFBP5, IGFBP7
MAP Kinase Signaling​
HRAS, MAP2K1, MAP2K3 (MEK3), MAP2K6 (MEK6, MKK6), MAPK14 (p38ALPHA)
Oxidative Stress​
ALDH1A3 (RALDH3), HRAS, MAPK14 (p38ALPHA), NOX4, PRKCD, SOD1, SOD2
DNA Damage & Repair​
ATM, GADD45A, NBN, PCNA, TERF2, TERT, TP53BP1
Senescence Responses
p53 Effectors​
ALDH1A3 (RALDH3), E2F1, HRAS, IGFBP3, MYC
p21 Effectors​
CALR
p16 Effectors​
TBX2, TBX3
Cytoskeleton Regulators​
AKT1, FN1, HRAS, PIK3CA (p110-alpha), PLAU (UPA), SERPINE1 (PAI-1), SPARC, THBS1 (TSP-1), VIM
Cell Adhesion Molecules​
CD44, COL1A1, COL3A1, TGFB1, TGFB1I1, THBS1 (TSP-1)
Other Senescence Response Genes​
GLB1, PTEN
Gene Resource List
Array Layout for PCR Plates
File Size: 153.25 KBLanguage: English
Array Layout for Rotor-Gene Q
File Size: 153.39 KBLanguage: English

Resources

Quick-Start Protocols (1)
Safety Data Sheets (1)
Kit Handbooks (1)
Certificates of Analysis (1)
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