GeneGlobe ID: SBHS-098Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels

QuantiNova LNA PCR Focus Panel Human mTOR Signaling

QuantiNova LNA PCR Focus Panel
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Product Specification

Target List
mTOR Complexes
mTORC1 Complex​
MLST8, MTOR, RPTOR
mTORC2 Complex​
MAPKAP1 (SIN1), MLST8, MTOR, RICTOR
mTOR Upstream Regulators
mTORC1 Positive Regulation​
AKT1, AKT2, AKT3, HRAS, IGF1, IKBKB (IKKβ), INS, INSR, IRS1, MAPK1 (ERK2), MAPK3 (ERK1), PDPK1, PIK3C3 (VPS34), PIK3CA (p110-alpha), PIK3CB, PIK3CD, PIK3CG, PLD1, PLD2, RHEB, RPS6KA1, RPS6KA2, RPS6KA5, RRAGA, RRAGB, RRAGC, RRAGD, TELO2
mTORC2 Positive Regulation​
AKT1, AKT2, AKT3, MAPK1 (ERK2), MAPK3 (ERK1), PDPK1, PIK3C3 (VPS34), PIK3CA (p110-alpha), PIK3CB, PIK3CD, PIK3CG, RHEB, RPS6KA1, RPS6KA2, RPS6KA5
mTORC1 Negative Regulation​
AKT1S1 (PRAS40), CAB39, CAB39L, DDIT4 (REDD1), DDIT4L (REDD2), DEPTOR, FKBP1A (FKBP12), FKBP8, IGFBP3, PRKAA1 (AMPK), PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTEN, STK11 (LKB1), STRADB, TP53 (p53), TSC1, TSC2, YWHAQ (14-3-3θ)
mTORC2 Negative Regulation​
CAB39, CAB39L, DDIT4 (REDD1), DDIT4L (REDD2), DEPTOR, PRKAA1 (AMPK), PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, STK11 (LKB1), STRADB, TSC1, TSC2
mTOR Downstream Effectors
mTORC1 Positive Regulation​
CHUK (IKKα), EIF4B, EIF4E, HIF1A, IKBKB (IKKβ), RPS6, RPS6KB1, RPS6KB2, TP53 (p53), VEGFA, VEGFB, VEGFC
mTORC2 Positive Regulation​
AKT1, CDC42, GSK3B, HSPA4 (HSP70), ILK, MYO1C, PRKCA, PRKCB, PRKCE, PRKCG, RHOA, RPS6KB1, SGK1
mTORC1 Negative Regulation​
EIF4EBP1 (4E-BP1), EIF4EBP2, PPP2CA, PPP2R2B, PTPA, TP53 (p53), ULK1, ULK2
Cellular Processes Regulated by mTOR Signaling
Amino Acid Response​
PIK3C3 (VPS34), RRAGA, RRAGB, RRAGC, RRAGD
Angiogenesis​
CHUK (IKKα), DDIT4 (REDD1), DDIT4L (REDD2), HIF1A, IKBKB (IKKβ), VEGFA, VEGFB, VEGFC
Autophagy​
PIK3C3 (VPS34), ULK1, ULK2
Cytoskeletal Organization​
CDC42, PRKCA, PRKCB, PRKCE, PRKCG, RHOA
Growth Factor Response​
HRAS, IGF1, IGFBP3, MAPK1 (ERK2), MAPK3 (ERK1), RPS6KA1, RPS6KA2, RPS6KA5
Energy Stress​
PRKAA1 (AMPK), PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3
Insulin Signaling​
AKT1, AKT2, AKT3, INS, INSR, IRS1, PDPK1, PIK3CA (p110-alpha), PIK3CB, PIK3CD, PIK3CG, TP53 (p53)
Lipid Metabolism​
PLD1, PLD2
Translation​
EIF4B, EIF4E, EIF4EBP1 (4E-BP1), EIF4EBP2, PPP2CA, PPP2R2B, PTPA, RPS6, RPS6KA1, RPS6KA2, RPS6KA5, RPS6KB1, RPS6KB2
Gene Resource List
Array Layout for PCR Plates
File Size: 153.06 KBLanguage: English
Array Layout for Rotor-Gene Q
File Size: 153.2 KBLanguage: English

Resources

Quick-Start Protocols (1)
Safety Data Sheets (1)
Kit Handbooks (1)
Certificates of Analysis (1)
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