Target List
Channels & Transporters
Water Transporters
Aqp1, Aqp2, Aqp3, Aqp4, Aqp5, Aqp9
Ion Channels
Cftr, Kcnj1, Mlc1, Trpv4
Other Transporters
Abcb1a (Mdr1), Atp1a1, Atp1b1, Lcn2 (Ngal), Slc12a2, Slc14a2, Slc2a1, Slc38a2, Slc6a12, Slc6a6, Slc9a1, Slc9a2, Slc9a3
TonEBP / OREBP (NFAT5) Targets
Aqp2, Slc14a2, Slc6a12, Slc6a6, Slc9a1
Hormones & Receptors
Adm, Agt, Agtr1a, Avp, Edn1, Guca2a, Ins2, Npr1, Oxt
Molecular Chaperones
Calr, Cryab, Hsp90aa1, Hspa1a (Hsp70-1), Hspa4 (Hsp70), Hspa4l, Hspa5 (Grp78), Hspb1 (Hsp27)
DNA Damage & Repair
Ddit3 (Gadd153, Chop), Gadd45a, Gadd45b, Gadd45g, Hmox1, Mapk1 (Erk2), Tp53 (p53)
Oxidative Stress
Cryab, Ddit3 (Gadd153, Chop), Dusp1, Egfr, Fos, Hmox1, Jun, Nos3 (eNOS), Tat, Tpm4
Regulation of Translation
Akt1, Calr, Hspb1 (Hsp27), Mapk1 (Erk2), Zfp36l1
Mitochondrial Genes
Akt1, Hsp90aa1, Hspa4 (Hsp70), Jun, Map3k1 (Mekk1), Nos3 (eNOS), Pck2, Tp53 (p53)
Cytoskeleton Regulators
Calr, Cryab, Edn1, Map3k1 (Mekk1), Ptk2 (Fak), Vim
Apoptosis
Akt1, Il1b, LOC100910732 (Pak2), Mapk8 (Jnk1), Nfkbia (Iκbα, Mad3), Sgk1, Vegfa
Cell Cycle
Akt1, Il1b
Cell Adhesion Molecules
Agt, Ccn2, Cd9, Egfr, Il1b, Itgb1, LOC103694380 (Tnf), Ptk2b (Pyk2)
Transcription Factors
Atf4, Ddit3 (Gadd153, Chop), Egr1, Egr3, Fos, Jun, Nfat5, Pax2, Snai1 (Snail, Sna), Tp53 (p53), Zfp36l1
Other Osmotic Stress Genes
LOC103694381 (Ltb), Map2k2 (Mek2), Odc1, Pdia4, Plat (tPA), Src, Tgfa