Target List
Genomic Instability
Bub1b, Mrpl43, Polrmt, Tfam, Tfb1m, Tfb2m, Zmpste24
Telomere Attrition
Pot1, Rap1a, Terf1, Terf2, Tinf2, Tpp1
Mitochondrial Dysfunction
Mrpl43, Ndufb11, Polrmt, Sirt3, Sirt6, Tfam, Tfb1m, Tfb2m
Proteostasis
Arl6ip6, Bub1b, Foxo1, Hsf1 (Tcf5), Jakmip3, Rnf144b, Txnip, Vps13c
Laminopathies
Lmna, Lmnb1, Lmnb2, Zmpste24
Neurodegeneration & Synaptic Transmission
Calb1, Gfap, Mbp, Scn2b, Snap23 (QuantiNova Symbol: AABR07053516.1)
Epigenetic Alterations
Arid1a, Sirt3, Sirt6
DNA Binding
Arid1a, Elp3, Ep300 (QuantiNova Symbol: AABR07058539.1), Fbxl16, Zbtb10, Zfp9, Zfr
RNA Binding
Elavl1, Lsm5, Zfr
Inflammatory Response
Angel2, Anxa3, Anxa5, C1qa, C1qb, C1qc, C1s, C3, C3ar1, C4a, C4b, C5ar1 (Gpr77), Ccr1, Cd14, Cd163, Cfh, Cfhr1, Cx3cl1, Cxcl16, Fcer1g, Fcgbp, Fcgr1a, Fcgr2a, Fcgr2b, Gfap, Ltf, Lyzl1, Mbp, Panx1, S100a8, S100a9, Tlr2, Tlr4, Tmem135, Tmem33, Tollip
Apoptosis
Casp1 (Ice), Clu, Ep300 (QuantiNova Symbol: AABR07058539.1), Pdcd6, Tollip
Cellular Senescence
Cdkn1c (p57KIP2), Vwa5a (QuantiNova Symbol: LOC108348048), Wrn
Cell Cycle
Bub1b, Cdkn1c (p57KIP2)
Cytoskeleton Regulators
Col1a1, Eml1
Oxidative Stress
Ep300 (QuantiNova Symbol: AABR07058539.1)
Transcriptional Regulation
Arid1a, Ep300 (QuantiNova Symbol: AABR07058539.1), Foxo1, Hsf1 (Tcf5), Phf3, Smad2