Target List
Pro-Fibrotic
Acta2, Agt, Ccl11 (Eotaxin), Ccl12, Ccl3 (Mip-1a), Ccn2, Grem1, Il13, Il13ra2, Il4, Il5, Snai1 (Snail, Sna)
Anti-Fibrotic
Bmp7, Hgf, Ifng, Il10, Il13ra2
Extracellular Matrix (ECM) & Cell Adhesion Molecules
Extracellular Matrix (ECM) Structural Constituents​
Col1a2, Col3a1
Extracellular Matrix (ECM) Remodeling Enzymes​
Lox, Mmp1, Mmp13, Mmp14, Mmp2, Mmp3, Mmp8, Mmp9, Plat (tPA), Plau (UPAM), Plg, Serpina1, Serpine1 (Pai-1), Serpinh1 (Hsp47), Timp1, Timp2, Timp3, Timp4
Cell Adhesion Molecules​
Itga1, Itga2, Itga3, Itgav, Itgb1, Itgb3, Itgb5, Itgb6, Itgb8
Inflammatory Cytokines & Chemokines
Ccl11 (Eotaxin), Ccl12, Ccl3 (Mip-1a), Ccr2, Cxcr4, Ifng, Il10, Il13, Il13ra2, Il1a, Il1b, Il4, Il5, Ilk, Tnf
Growth Factors
Agt, Ccn2, Edn1, Egf, Hgf, Pdgfa, Pdgfb, Vegfa
Signal Transduction
TGFβ Superfamily Members​
Bmp7, Cav1, Dcn, Eng (Evi-1), Grem1, Inhbe, Ltbp1, Smad2, Smad3, Smad4, Smad6, Smad7, Tgfb1, Tgfb2, Tgfb3, Tgfbr1 (Alk5), Tgfbr2, Tgif1, Thbs1 (TSP-1, Tsp1), Thbs2
Transcription Factors​
Cebpb, Jun, Myc, Nfkb1, Sp1, Stat1, Stat6
Epithelial-to-Mesenchymal Transition (EMT)
Akt1, Bmp7, Col1a2, Col3a1, Ilk, Itgav, Itgb1, Mmp2, Mmp3, Mmp9, Serpine1 (Pai-1), Smad2, Snai1 (Snail, Sna), Tgfb1, Tgfb2, Tgfb3, Timp1
Other Fibrosis Genes
Bcl2, Faslg