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Hepatic Fibrosis / Hepatic Stellate Cell Activation

Hepatic fibrosis is a chronic liver disease associated with an accumulation of extracellular matrix (ECM) proteins. Causative agents include hepatotoxins like excessive ethanol, bile acids, glucose and free fatty acids. Hepatotoxins initiate a cascade of pro-inflammatory events which eventually activate Hepatic stellate cells (HSCs). Activated HSCs secrete cytokines that perpetuate their activated state. Continued liver injury results in an accumulation of activated HSCs and myofibroblasts which in turn synthesize large amounts of ECM, mainly collagen, leading to tissue fibrosis and eventually to liver cirrhosis...

Hepatic Fibrosis / Hepatic Stellate Cell Activation

Pathway Summary

Hepatic fibrosis is a chronic liver disease associated with an accumulation of extracellular matrix (ECM) proteins. Causative agents include hepatotoxins like excessive ethanol, bile acids, glucose and free fatty acids. Hepatotoxins initiate a cascade of pro-inflammatory events which eventually activate Hepatic stellate cells (HSCs). Activated HSCs secrete cytokines that perpetuate their activated state. Continued liver injury results in an accumulation of activated HSCs and myofibroblasts which in turn synthesize large amounts of ECM, mainly collagen, leading to tissue fibrosis and eventually to liver cirrhosis.

Hepatic Fibrosis / Hepatic Stellate Cell Activation Genes list

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GeneGlobe ID: UPHS-093Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Hepatotoxicity
QuantiNova LNA Probe PCR Focus Panel
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GeneGlobe ID: UPHS-120Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Fibrosis
QuantiNova LNA Probe PCR Focus Panel
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GeneGlobe ID: SBHS-093Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Hepatotoxicity
QuantiNova LNA PCR Focus Panel
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GeneGlobe ID: SBHS-120Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Fibrosis
QuantiNova LNA PCR Focus Panel
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GeneGlobe ID: PAHS-093Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Hepatoxicity
RT2 Profiler PCR Array
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GeneGlobe ID: PAHS-120Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Fibrosis
RT2 Profiler PCR Array
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