Target List
NFÎşB Signaling
Ikbkb (IKK2), Nfkb1, Nfkbia (Iκbα, Mad3), Rela, Tlr4
Cytokines
Ccl12, Ccl3 (Mip-1a), Ccl4 (Mip-1b), Ccl5 (Rantes), Cd40lg, Csf1 (Mcsf), Csf2 (Gm-csf), Csf2 (Gm-csf), Csf2 (Gm-csf), Csf3 (Gcsf), Cxcl3, Cxcl10 (Inp10), Cxcl12, Faslg, Il10, Il11, Il13, Il15, Il18, Il1a, Il1b, Il2, Il20, Il21, Il22, Il23a, Il24, Il3, Il4, Il5, Il6, Il7, Il9, Lif, Lta (Tnfb), Osm, Tnf, Tnfsf10 (Trail), Tnfsf11 (Rankl)
IL6 / STAT3 Signaling
STAT3 Activators​
Cxcl12, Egfr, Il10, Il11, Il21, Il23a, Il6
Cell Surface Receptors​
Cd4, Cd40, Cd80, Csf3r, Cxcr4, Fas, Il18r1, Il1r1, Il2ra (Cd25), Il6st (Gp130), Lifr, Osmr, Tnfrsf10b (QuantiNova Symbol: AABR07018323.1), Tnfrsf1a (Tnfr1), Tnfrsf1b
Signaling Upstream of IL6 / STAT3​
Akt1, Jak2, Jak3, Map2k1 (MEK1), Mapk1 (Erk2), Mapk14 (p38alpha), Mapk3 (ERK1), Mapk8 (Jnk1), Mtor, Myc, Pias3, Rac1, Socs1, Socs3, Src, Tyk2
Signaling Downstream of IL6 / STAT3​
Bax, Bcl2, Cdc25a, Cdkn1a (Cip1, Waf1), Hgf, Met, Pim1, Stat3
IL6 / STAT3 Signaling Target Genes​
Ccl12, Ccl5 (Rantes), Cd80, Cebpd, Cxcl10 (Inp10), Cxcl12, Il10, Il11, Il12a, Il1b, Il21, Il6, Myc, Socs3