icon_0328_cc_gen_hmr_bacteria-s

Macropinocytosis Signaling

Different mechanisms are available for the endocytic internalization of a variety of particles (Eg molecules, viruses, bacteria), including clathrin-mediated endocytosis, caveolar endocytosis, macropinocytosis and non-clathrin, non-caveolae endocytosis. Macropinocytosis refers to the actin-dependent formation of large endocytic vesicles of irregular size and shape called macropinosomes. This process involves an extensive plasma membrane reorganization and internalization of large quantities of extracellular fluid. Macropinocytosis depends on signaling to the actin cytoskeleton and therefore is highly dependent on the activity of Rho family members, Rac1, RhoA and Cdc42, and their upstream effectors such as Ras and PI3K. Src, PLCγ, and PKC are also involved in the extensive actin rearrangement, which leads to membrane ruffling and formation of macropinosomes...

Macropinocytosis Signaling

Pathway Summary

Different mechanisms are available for the endocytic internalization of a variety of particles (Eg molecules, viruses, bacteria), including clathrin-mediated endocytosis, caveolar endocytosis, macropinocytosis and non-clathrin, non-caveolae endocytosis. Macropinocytosis refers to the actin-dependent formation of large endocytic vesicles of irregular size and shape called macropinosomes. This process involves an extensive plasma membrane reorganization and internalization of large quantities of extracellular fluid. Macropinocytosis depends on signaling to the actin cytoskeleton and therefore is highly dependent on the activity of Rho family members, Rac1, RhoA and Cdc42, and their upstream effectors such as Ras and PI3K. Src, PLCγ, and PKC are also involved in the extensive actin rearrangement, which leads to membrane ruffling and formation of macropinosomes. Two types of macropinosomes can be generated, the recycling macropinosomes and the processive macropinosomes. Recycling macropinosmes are formed upon binding of ligands such as EGF, PDGF, NGF and Insulin to Receptor Tyrosine Kinase (RTK), the vesicles travel then into the cytosol, where their content is released or the macropinosomes are recycled back to the cell surface, where their content is released into the extracellular space. The processive macropinosomes are triggered by diverse receptors, including Integrins, the mannose receptor MRC1 or the lipopolysaccharide receptor CD14 and are involved in the uptake of antigen, bacteria, viruses, and apoptotic cells. The processive macropinosomes shrink in size and fuse with late endosomes and lysosomes.

Macropinocytosis Signaling Genes list

Explore Genes related to Macropinocytosis Signaling

Products related to Macropinocytosis Signaling

Explore products related to Macropinocytosis Signaling
GeneGlobe ID: UPHS-160Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human IL6/STAT3 Signaling Pathway
QuantiNova LNA Probe PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: SBHS-058Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human PI3K-AKT Signaling Pathway
QuantiNova LNA PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: UPHS-040Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human EGF / PDGF Signaling Pathway
QuantiNova LNA Probe PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: UPHS-088Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Cytoskeleton Regulators
QuantiNova LNA Probe PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: SBHS-040Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human EGF / PDGF Signaling Pathway
QuantiNova LNA PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: SBHS-088Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Cytoskeleton Regulators
QuantiNova LNA PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: SBHS-160Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human IL6/STAT3 Signaling Pathway
QuantiNova LNA PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: UPHS-058Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human PI3K-AKT Signaling Pathway
QuantiNova LNA Probe PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: PAHS-040Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human EGF / PDGF Signaling Pathway
RT2 Profiler PCR Array
Product Specification
Copy Details
GeneGlobe ID: PAHS-058Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human PI3K-AKT Signaling Pathway
RT2 Profiler PCR Array
Product Specification
Copy Details
GeneGlobe ID: PAHS-088Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Cytoskeleton Regulators
RT2 Profiler PCR Array
Product Specification
Copy Details

Didn't find what you're looking for?

Discover other products relevant to this gene list with our Panel Finder. Check it out.