FBXL15 Gene Summary [Human]
Involved in G2/M transition of mitotic cell cycle; cellular protein metabolic process; and positive regulation of BMP signaling pathway. Located in cytoplasm. Part of SCF ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | FBXL15 |
| Official Name | F-box and leucine rich repeat protein 15 [Source:HGNC Symbol;Acc:HGNC:28155] |
| Ensembl ID | ENSG00000107872 |
| Bio databases IDs | |
| Aliases | F-box and leucine rich repeat protein 15 |
| Synonyms | 0710008C12Rik, Fbl15, F-box and leucine-rich repeat protein 15, FBXO37, JET, PSD, RGD1306444 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FBXL15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain superfamily
- Leucine-rich repeat - CC (cysteine-containing) subfamily
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FBXL15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of BMP signaling pathway
- G2/M transition of mitotic cell cycle
- bone mineralization
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- dorsal/ventral pattern formation
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- SCF ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- protein binding