FIRRE Gene Summary [Human]
This gene produces a long RNA containing a repeating sequence. This RNA interacts with heterogeneous nuclear ribonucleoprotein U and coats chromosomes, where it plays an important role in the maintenance of repressive chromatin. This transcript can also act post-transcriptionally to regulate the stability of mRNAs during the innate immune response. [provided by RefSeq, Dec 2017]
Details
| Type | Long Non-Coding RNA |
| Official Symbol | FIRRE |
| Official Name | firre intergenic repeating RNA element [Source:HGNC Symbol;Acc:HGNC:49627] |
| Ensembl ID | ENSG00000213468 |
| Bio databases IDs | |
| Aliases | firre intergenic repeating RNA element, functional intergenic repeating RNA element |
| Synonyms | 5830467J12Rik, 6720401G13Rik, firre intergenic repeating RNA element, functional intergenic repeating RNA element, LINC01200, LOC100047264, LOC286467 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FIRRE often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding activity, bridging
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- metastasis
- obesity
- lung adenocarcinoma
- lung adenocarcinoma formation
- osteosarcoma
- osteosarcomagenesis
- organismal death
role in cell
- expression in
- migration
- invasion by
- proliferation
- binding in
- M1 polarization
- frequency
- organization
- autophagy in
- M2 polarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- autosome
- nucleoplasm
- Barr body
- X chromosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FIRRE gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin organization
Cellular Component
Where in the cell the gene product is active
- Barr body
- X chromosome
- autosome
Molecular Function
What the gene product does at the molecular level
- protein binding