CUL1 Gene Summary [Human]
Predicted to enable ubiquitin protein ligase binding activity and ubiquitin-protein transferase activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Located in plasma membrane. Part of Parkin-FBXW7-Cul1 ubiquitin ligase complex and SCF ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CUL1 |
| Official Name | cullin 1 [Source:HGNC Symbol;Acc:HGNC:2551] |
| Ensembl ID | ENSG00000055130 |
| Bio databases IDs | |
| Aliases | cullin 1 |
| Synonyms | cullin 1, CULLIN HOMOLOG 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CUL1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- Nedd8 binding domain
- protein binding activity, bridging
- Cullin protein neddylation domain
- Cullin family
- Ubc binding domain
- enzyme
- protein binding
- neddylation domain
- Cullin
Pathways
Biological processes and signaling networks where the CUL1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-insulin-dependent diabetes mellitus
- cancer
- inflammatory bowel disease
- osteogenesis imperfecta type III
- infectious mononucleosis
- hypoplasia
- Crohn disease
- hematological neoplasia
- systemic lupus erythematosus
role in cell
- binding in
- apoptosis
- proliferation
- activation in
- phosphorylation in
- quantity
- growth
- cell death
- migration
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Plasma Membrane
- centrosome
- centriole
- midbody
- cytosol
- nucleoplasm
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CUL1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- proteasomal ubiquitin-dependent protein catabolic process
- protein K48-linked ubiquitination
- G1/S transition of mitotic cell cycle
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- intrinsic apoptotic signaling pathway
- protein monoubiquitination
- protein ubiquitination
- organ morphogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cullin-RING ubiquitin ligase complex
- cytoplasm
- cytosol
- SCF ubiquitin ligase complex
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin protein ligase binding
- protein binding
- protein binding, bridging