ARIH1 Gene Summary [Human]
Enables enzyme binding activity; ubiquitin-protein transferase activity; and zinc ion binding activity. Involved in protein ubiquitination. Located in Lewy body; cytoplasm; and nuclear body. Colocalizes with cullin-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ARIH1 |
| Official Name | ariadne RBR E3 ubiquitin protein ligase 1 [Source:HGNC Symbol;Acc:HGNC:689] |
| Ensembl ID | ENSG00000166233 |
| Bio databases IDs | |
| Aliases | ariadne RBR E3 ubiquitin protein ligase 1, ariadne, Drosophila, homolog of |
| Synonyms | ARI, Ari1, ariadne RBR E3 ubiquitin protein ligase 1, HARI, HHARI, LOC102723628, UBCH7BP, Uip77 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARIH1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- glycine rich domain
- IBR domain, a half RING-finger domain
- enzyme binding
- BRcat_Rcat_RBR
- enzyme
- protein binding
- acidic domain
- ubiquitin ligase-like domain
- ubiquitin-like protein transferase activity
- zinc ion binding
- In Between Ring fingers
- spacer domain
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ubiquitin-protein transferase activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- rheumatoid arthritis
- aortic aneurysm
- posterior cortical atrophy
- Alzheimer disease
- atopic dermatitis
role in cell
- expression in
- phosphorylation in
- proliferation
- degradation in
- activation
- ubiquitination in
- cellular infiltration by
- CSN5i-3 sensitivity
- cisplatin resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular space
- perinuclear region
- Nucleus
- cytosol
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ARIH1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein polyubiquitination
- ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- ubiquitin ligase complex
- cytoplasm
- Cajal body
- Cul4A-RING ubiquitin ligase complex
- cytosol
- Cul2-RING ubiquitin ligase complex
- SCF ubiquitin ligase complex
- Cul3-RING ubiquitin ligase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- zinc ion binding
- ubiquitin conjugating enzyme binding
- ubiquitin protein ligase binding
- protein binding
- small conjugating protein ligase activity