Rabgap1 Gene Summary [Mouse]
Predicted to enable GTPase activator activity and small GTPase binding activity. Predicted to be located in cytosol. Orthologous to human RABGAP1 (RAB GTPase activating protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rabgap1 |
| Official Name | RAB GTPase activating protein 1 [Source:MGI Symbol;Acc:MGI:2385139] |
| Ensembl ID | ENSMUSG00000035437 |
| Bio databases IDs | |
| Aliases | RAB GTPase activating protein 1 |
| Synonyms | GAP Associated, GAPCENA, mKIAA4104, RAB GTPase activating protein 1, TBC1D11 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rabgap1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rab-GTPase-TBC domain
- Mechanosensitive ion channel porin domain
- Kinesin protein
- Ezrin/radixin/moesin, alpha-helical domain
- tubulin binding
- Domain in Tre-2, BUB2p, and Cdc16p
- enzyme binding
- GTPase activator
- protein binding
- Pleckstrin homology-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- insomnia
- spondylarthritis
- vertigo
regulates
- GTPase
role in cell
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centrosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rabgap1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of GTPase activity
Cellular Component
Where in the cell the gene product is active
- centrosome
- cytosol
- microtubule associated complex
Molecular Function
What the gene product does at the molecular level
- tubulin binding
- protein binding
- GTPase activator activity
- small GTPase binding