Stx18 Gene Summary [Mouse]
Enables protein domain specific binding activity. Predicted to be involved in several processes, including positive regulation of ER to Golgi vesicle-mediated transport; regulation of organelle organization; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to be located in Golgi membrane and endoplasmic reticulum membrane. Predicted to be part of SNARE complex. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and limb. Orthologous to human STX18 (syntaxin 18). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stx18 |
| Official Name | syntaxin 18 [Source:MGI Symbol;Acc:MGI:1918366] |
| Ensembl ID | ENSMUSG00000029125 |
| Bio databases IDs | |
| Aliases | syntaxin 18 |
| Synonyms | 1810035L21Rik, 4933425D03Rik, syntaxin 18, Ufe1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Stx18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE-complex protein Syntaxin-18 N-terminus
- transmembrane domain
- protein domain specific binding
- protein binding
- SNARE motif
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- idiopathic scoliosis
role in cell
- expression in
- migration
- survival
- assembly
- invasion by
- organization
- aggregation
- phagocytosis
- scattering
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- vesicles
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Stx18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane fusion
- retrograde vesicle-mediated transport, Golgi to ER
- endoplasmic reticulum membrane organization
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- SNARE complex
- endoplasmic reticulum
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- protein binding
- SNAP receptor activity