Bcas2 Gene Summary [Mouse]
Acts upstream of or within several processes, including alternative mRNA splicing, via spliceosome; ovarian follicle development; and spindle assembly. Part of Prp19 complex. Is expressed in several structures, including central nervous system; early conceptus; oocyte; peripheral nervous system ganglion; and submandibular gland primordium. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human BCAS2 (BCAS2 pre-mRNA processing factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bcas2 |
| Official Name | breast carcinoma amplified sequence 2 [Source:MGI Symbol;Acc:MGI:1915433] |
| Ensembl ID | ENSMUSG00000005687 |
| Bio databases IDs | |
| Aliases | breast carcinoma amplified sequence 2 |
| Synonyms | 6430539P16Rik, BCAS2 pre-mRNA processing factor, BCAS2, pre-mRNA processing factor, DAM1, Snt309, SPF27 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bcas2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Breast carcinoma amplified sequence 2 (BCAS2)
- coiled-coil domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- proliferation
- activation in
- apoptosis
- quantity
- phosphorylation in
- expression in
- G1 phase
- development
- splicing by
- alternative splicing by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- catalytic step 2 spliceosome
- centrosome
- spliceosomes
- nucleoplasm
- nucleoli
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bcas2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing, via transesterification reactions
- RNA splicing
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- catalytic step 2 spliceosome
- nuclear speck
- spliceosomal complex
- U2-type catalytic step 2 spliceosome
- DNA replication factor A complex
- Prp19 complex
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding