Vcp Gene Summary [Mouse]
Enables several functions, including ATP hydrolysis activity; K48-linked polyubiquitin modification-dependent protein binding activity; and adenyl ribonucleotide binding activity. Involved in ATP metabolic process; positive regulation of mitochondrial membrane potential; and proteasomal protein catabolic process. Acts upstream of or within aggresome assembly and ubiquitin-dependent protein catabolic process. Located in endoplasmic reticulum membrane. Part of several cellular components, including VCP-NSFL1C complex; cytoplasmic ubiquitin ligase complex; and endoplasmic reticulum membrane. Is active in synapse. Is expressed in several structures, including cerebral cortex; early embryo; gonad; gut; and triceps surae muscle. Used to study frontotemporal dementia and inclusion body myopathy with Paget disease of bone and frontotemporal dementia. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2Y; Paget's disease of bone; frontotemporal dementia and/or amyotrophic lateral sclerosis 6; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1; and inclusion body myositis. Orthologous to human VCP (valosin containing protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vcp |
| Official Name | valosin containing protein [Source:MGI Symbol;Acc:MGI:99919] |
| Ensembl ID | ENSMUSG00000028452 |
| Bio databases IDs | |
| Aliases | valosin containing protein |
| Synonyms | 3110001E05, CDC48, FTDALS6, IBMPFD, p97, p97/VCP, TERA, Ter atpase, Transitional Endoplasmic Reticulum Atpase, valosin-containing protein, XSG7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vcp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- AAA ATPase domain
- MHC class I protein binding
- walker type B motif
- ATP-binding domain
- ADP binding
- ATP binding
- protein binding activity, bridging
- enzyme
- protease activator
- identical protein binding
- ATPase
- Cell division protein 48 (CDC48) N-terminal domain
- ATPase domain
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
- ubiquitin protein ligase binding
- AAA family ATPase, CDC48 subfamily
- protease binding
- protein phosphatase binding
- walker type A motif
- enzyme binding
- protein domain specific binding
- Cell division protein 48 (CDC48), N-terminal domain
- protein binding
- AAA+ lid domain
- AAA domain (dynein-related subfamily)
- ATPase family associated with various cellular activities (AAA)
- binding protein
- Cell division protein 48 (CDC48), domain 2
Pathways
Biological processes and signaling networks where the Vcp gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- lymphoma
- lymphomagenesis
- Alzheimer disease
- liver cancer
- inclusion body myopathy with early-onset Paget disease and frontotemporal dementia type 1
- frontotemporal dementia without amyotrophic lateral sclerosis type 6
- amyotrophic lateral sclerosis with dementia
- global developmental delay
role in cell
- expression in
- growth
- migration
- proliferation
- cell death
- number
- accumulation in
- invasion
- degradation in
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- nuclear fraction
- low-density microsomal fraction
- membrane fraction
- detergent resistant lipid raft fraction
- glutaminergic synapse
- endoplasmic reticulum mitochondria contact site
- intracellular membrane-bounded organelle
- secretory granule lumen
- ficolin-1-rich granule lumen
- azurophil granule lumen
- Extracellular Space
- intranuclear region
- perinuclear region
- Nucleus
- basal bodies
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- lipid droplets
- cytosol
- endoplasmic reticulum membrane
- microsome
- nucleoplasm
- nucleoli
- growth cone
- synaptosomes
- synapse
- smooth endoplasmatic reticulum
- stress granule
- microsomal membrane
- chromatin
- exosomes
- detergent-soluble fraction
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vcp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- positive regulation of ATP biosynthetic process
- double-strand break repair
- NADH metabolic process
- positive regulation of mitochondrial membrane potential
- cellular response to heat
- flavin adenine dinucleotide catabolic process
- stress granule disassembly
- endoplasmic reticulum unfolded protein response
- autophagy
- aggresome assembly
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- mitotic spindle disassembly
- translesion synthesis
- macroautophagy
- positive regulation of protein complex assembly
- cellular response to misfolded protein
- proteasomal protein catabolic process
- regulation of synapse organization
- positive regulation of canonical Wnt receptor signaling pathway
- positive regulation of protein catabolic process
- regulation of apoptotic process
- response to DNA damage stimulus
- negative regulation of smoothened signaling pathway
- ubiquitin-dependent protein catabolic process
- establishment of protein localization
- ER to Golgi vesicle-mediated transport
- proteasomal ubiquitin-dependent protein catabolic process
- ATP metabolic process
- endosome to lysosome transport via multivesicular body sorting pathway
- viral genome replication
- retrograde protein transport, ER to cytosol
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasmic stress granule
- site of double-strand break
- Cdc48p-Npl4p-Ufd1p AAA ATPase complex
- endoplasmic reticulum
- proteasome complex
- extracellular region
- nucleoplasm
- lipid particle
- endoplasmic reticulum membrane
- nucleus
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- macromolecular complex
- secretory granule lumen
- azurophil granule lumen
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- identical protein binding
- protein domain specific binding
- protein phosphatase binding
- polyubiquitin binding
- lipid binding
- MHC class I protein binding
- ADP binding
- small conjugating protein ligase binding
- ATP binding
- RNA binding
- ubiquitin protein ligase binding
- protein binding
- ubiquitin-specific protease activator activity