Rab4a Gene Summary [Mouse]
Predicted to enable several functions, including ATPase binding activity; guanyl ribonucleotide binding activity; and ionotropic glutamate receptor binding activity. Involved in neurotransmitter receptor transport postsynaptic membrane to endosome and vesicle-mediated transport in synapse. Acts upstream of or within protein transport; regulation of endocytosis; and small GTPase-mediated signal transduction. Located in endosome. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; genitourinary system; gut; liver and biliary system; and primitive endoderm. Orthologous to human RAB4A (RAB4A, member RAS oncogene family). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rab4a |
| Official Name | RAB4A, member RAS oncogene family [Source:MGI Symbol;Acc:MGI:105069] |
| Ensembl ID | ENSMUSG00000019478 |
| Bio databases IDs | |
| Aliases | RAB4A, member RAS oncogene family |
| Synonyms | HRES-1, HRES-1/RAB4, RAB4, RAB4A, member RAS oncogene family |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rab4a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase stimulator
- Ras family
- enzyme
- geranylgeranylation site
- effector domain
- syntaxin binding
- nucleotide-binding domain
- CXC geranylgeranylation motif
- Elongation factor Tu GTP binding domain
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
- GTP binding domain
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- 50S ribosome-binding GTPase
- alpha helix
- GTPase
- protein binding
- ionotropic glutamate receptor binding
- Ras subfamily of RAS small GTPases
- GTP binding
- ATPase binding
- ADP-ribosylation factor family
- small GTP-binding protein domain
- GTPase domain
- GDP binding
- Rab subfamily of small GTPases
Pathways
Biological processes and signaling networks where the Rab4a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- peripheral arterial disease
- Waldenström macroglobulinemia
role in cell
- expression in
- activation in
- activation
- quantity
- size
- degradation in
- accumulation
- length
- budding
- self-renewal
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- soluble fraction
- golgi/trans-golgi network-rich vesicle fraction
- low-density microsomal fraction
- detergent-insoluble fractions
- membrane fraction
- insoluble fractions
- endosomal membrane fractions
- intracellular nanovesicle
- synaptic vesicle membrane
- glutaminergic synapse
- cytoplasmic vesicle membrane
- cell periphery
- perinuclear region
- intracellular membranes
- cellular membrane
- vacuole
- Plasma Membrane
- endosomes
- vesicles
- cytosol
- apical membrane
- trans face of the Golgi apparatus
- Golgi stacks
- endosomal membrane
- recycling endosomes
- early endosomes
- perinuclear vesicles
- cytoplasmic vesicles
- tight junctions
- secretory granules
- microsomal membrane
- sorting endosomes
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rab4a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle-mediated transport
- Rab protein signal transduction
- protein transport
- antigen processing and presentation
- regulation of endocytosis
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- cytoplasmic vesicle membrane
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- insulin-responsive compartment
- vesicle
- recycling endosome membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- small monomeric GTPase activity
- GDP binding