RT1-Da Gene Summary [Rat]
Predicted to enable several functions, including MHC class II protein complex binding activity; T cell receptor binding activity; and peptide antigen binding activity. Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class II; antigen processing and presentation of exogenous peptide antigen via MHC class II; and regulation of T cell differentiation. Predicted to act upstream of or within immunoglobulin mediated immune response. Predicted to be located in external side of plasma membrane; immunological synapse; and lysosome. Predicted to be part of MHC class II protein complex. Predicted to be active in late endosome membrane and lysosomal membrane. Biomarker of prediabetes syndrome. Human ortholog(s) of this gene implicated in Parkinson's disease (multiple); allergic disease; asthma; and autoimmune disease (multiple). Orthologous to human HLA-DRA (major histocompatibility complex, class II, DR alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | RT1-Da |
| Official Name | RT1 class II, locus Da [Source:RGD Symbol;Acc:1593283] |
| Ensembl ID | ENSRNOG00000032844 |
| Bio databases IDs | |
| Aliases | RT1 class II, locus Da |
| Synonyms | DA1, H2-Ea, Histocompatibility 2, class II antigen E alpha, Histocompatibility 2, class II antigen E α, HLA CLASS II, HLA CLASS II HISTOCOMPATIBILITY ANTIGEN alpha CHAIN precursor, HLA CLASS II HISTOCOMPATIBILITY ANTIGEN α CHAIN precursor, HLA-DRA1, HLA-DR alpha, HLA-DR ANTIGEN alpha CHAIN, HLA-DR ANTIGEN α CHAIN, HLA-DR α, major histocompatibility complex, class II, DR alpha, major histocompatibility complex, class II, DR α, MHC-DRA, MHCIIalpha, MHCIIα, MLRW, RT1 class II, locus Da, RT1-Da, RT1-u |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rt1-Da often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Immunoglobulin C1-set domain
- immunoglobulin domain
- transmembrane domain
- Class II histocompatibility antigen, alpha domain
- T-cell receptor binding
- protein binding
- polysaccharide binding
- transmembrane receptor
- peptide antigen binding
Pathways
Biological processes and signaling networks where the Rt1-Da gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- Parkinson disease
- systemic lupus erythematosus
- T-cell non-Hodgkin disease
- Sjögren syndrome
- osteoporosis
- sarcoidosis
- asthma
- primary biliary cirrhosis
- atopic dermatitis
regulates
- HA
- DNA promoter
- DNA endogenous promoter
role in cell
- activation in
- activation
- cytotoxicity
- differentiation
- interferon gamma response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- endocytic vesicle membrane
- cytoplasmic vesicle membrane
- cell surface
- cellular membrane
- vesicles
- lysosome
- Endoplasmic Reticulum
- immunological synapses
- MHC class II compartments
- plasma membrane extracellular face
- Golgi membrane
- trans Golgi network
- lysosome membrane
- endosomal membrane
- membrane rafts
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rt1-Da gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- antigen processing and presentation of endogenous peptide antigen via MHC class II
- regulation of T-helper cell differentiation
- adaptive immune response
- positive regulation of T cell activation
- myeloid dendritic cell antigen processing and presentation
- immune response
- peptide antigen assembly with MHC class II protein complex
- cognition
- antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
- positive regulation of memory T cell differentiation
- positive regulation of CD4-positive, alpha-beta T cell activation
- positive regulation of T cell mediated cytotoxicity
- antigen processing and presentation of exogenous peptide antigen via MHC class II
- positive regulation of immune response
- positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
Cellular Component
Where in the cell the gene product is active
- MHC class II protein complex
- Golgi membrane
- lysosomal membrane
- plasma membrane
- immunological synapse
- cell surface
- lysosome
- early endosome membrane
- late endosome membrane
- transport vesicle membrane
- clathrin-coated endocytic vesicle membrane
- extracellular vesicular exosome
- ER to Golgi transport vesicle membrane
- trans-Golgi network membrane
- endocytic vesicle membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- peptide antigen binding
- MHC class II receptor activity
- T cell receptor binding
- MHC class II protein complex binding
- polysaccharide binding