icon_0328_cc_gen_hmr_bacteria-s

IL-4 Signaling

Interleukin 4 (IL-4) is a cytokine associated with allergy and asthma. The classical IL-4R is predominantly expressed in hematopoietic cells and consists of IL-4Rα and IL-2Rγc. The alternative form of IL-4R is predominantly expressed in non-hematopoietic cells and consists of IL-4R and IL-13Ralpha chains.IL-4 binding to its receptor activates JAK/TYK2 followed by phosphorylation and dimerization of STAT6. The transcriptional regulator STAT6 is able to induce various genes that are involved immune function like IgE and MHC-II...

IL-4 Signaling

Pathway Summary

Interleukin 4 (IL-4) is a cytokine associated with allergy and asthma. The classical IL-4R is predominantly expressed in hematopoietic cells and consists of IL-4Rα and IL-2Rγc. The alternative form of IL-4R is predominantly expressed in non-hematopoietic cells and consists of IL-4R and IL-13Ralpha chains.IL-4 binding to its receptor activates JAK/TYK2 followed by phosphorylation and dimerization of STAT6. The transcriptional regulator STAT6 is able to induce various genes that are involved immune function like IgE and MHC-II. IL-4 induced STAT-6 function can be inhibited by corticosteroids while JAK1 is strongly inhibited by SOCS-1. An alternate pathway involves the IL-4R mediated tyrosyl phosphorylation of IRS-1 followed by activation of the PI3K/AKT/mTOR/p70RSK pathway.

IL-4 Signaling Genes list

Explore Genes related to IL-4 Signaling

Products related to IL-4 Signaling

Explore products related to IL-4 Signaling
GeneGlobe ID: UPHS-021Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Common Cytokines
QuantiNova LNA Probe PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: SBHS-021Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Common Cytokines
QuantiNova LNA PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: SBHS-150Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Cytokines & Chemokines
QuantiNova LNA PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: UPHS-150Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Cytokines & Chemokines
QuantiNova LNA Probe PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: PAHS-150Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Cytokines & Chemokines
RT2 Profiler PCR Array
Product Specification
Copy Details
GeneGlobe ID: PAHS-021Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Common Cytokines
RT2 Profiler PCR Array
Product Specification
Copy Details

Didn't find what you're looking for?

Discover other products relevant to this gene list with our Panel Finder. Check it out.